Grosshadern Hospital
Grosshadern Hospital ©Klinikum der Universität München, Klinikum Großhadern


Grosshadern Campus, Munich University Hospital

Specialist field: Urology

Prof. Dr. med. Christian G. Stief

Marchioninistraße 15
81377 München
PD Dr. med. Alexander Roosen
+ 49 (0) 89 7095 8744

Professor Christian Stief

Director of the Urological Clinic and Department, Grosshadern Campus, Munich University Hospital


AR | DE | EN | RU

Medical travel

Expert medical care at hospitals and rehabilitation clinics

Medical travel

Expert medical care at hospitals and rehabilitation clinics

Professor Christian G. Stief: Focal therapy for prostate carcinoma – a European phase III trial

In cases of prostate cancer, the use of active surveillance (or ’watchful waiting’) can delay or prevent entirely the need for a radical operation that – despite improved surgical techniques – can cause incontinence and impotence. It should not be underestimated, however, how stressful it can be knowing you have cancer but not actively doing anything about it.

The newly developed procedure of focal therapy for prostate carcinoma offers a third way: targeted elimination of the primary cancer in a way that leaves the organ intact and retains its function. We are offering this concept as part of a European multicentre phase III trial aimed at obtaining regulatory approval for the treatment.

What type of patients are suitable for focal therapy as a non-aggressive means of treating prostate cancer?

Professor Stief: The same criteria apply as for the clinical trial on active surveillance: the PSA level should be no higher than 10 ng/ml; the Gleason score (a histological grading system indicating the stage of prostate cancer) should be no higher than six; a maximum of only three biopsies should return positive results; the prostate may only be of a certain size and no preliminary treatment of urethral stricture should have taken place – all these criteria indicate the presence of a localised and slow-growing prostate tumour. An MRI scan is also carried out to determine the precise size and location of the tumour. The data for all European hospitals participating in the study is evaluated centrally by a team of highly regarded experts. If the patient proves suitable for focal therapy, the tumour is identified and can then be removed with pinpoint precision.

How is the therapy performed?

Professor Stief: The actual therapy is performed on an inpatient basis involving a single overnight hospital stay. On the day before the operation, the patient is seen by the anaesthetist; on the day of treatment itself, the approx. 90 minute operation is carried out under general anaesthetic. During the operation, a substance is delivered to the tumour that can be activated by a laser, completely destroying the blood vessels that supply nutrients to the tumour. This causes a circumscribed tissue defect that will ideally encompass the entire primary cancer. The patient is then able to leave the hospital the same day after only a short stay in the recovery room.

What are the side effects of the therapy?

Professor Stief: Patients usually report only minor or moderate complaints such as a burning sensation while urinating and/or a more frequent need to urinate for a few days after the operation. In exceptional cases, patients have difficulty urinating and have to be temporarily fitted with a catheter. Continence and potency are unimpaired and the patient can return to work just one day after treatment.

How is the success rate of the treatment monitored?

Professor Stief: The patient must be continually monitored as part of the treatment and should return to us for a check-up every three months for a period of two years. Monitoring PSA levels after the operation tells us less because the bulk of the PSA-producing prostate tissue is preserved. Cross-sectional imaging is the most important tool for evaluating the post-operative situation (MRI: after a week, after 12 and 24 months). A punch biopsy is carried out after one year and again after two. The data gathered in the phase II clinical trial (40 patients) is extremely encouraging: in all cases in which at least 80 per cent of the target volume that was treated is shown to have declined in the post-operative crosssectional imaging, there have been no cases of remaining tumour tissue. Continence and potency are also completely preserved. Should there be evidence of remaining tumour tissue, options include further focal therapy, traditional radiotherapy and radical surgery.

To find out more, prospective patients can attend our prostate carcinoma consultation held every Friday (for appointments call +49 (0)89 7095 3530; Dr A. Roosen).

Discover Destination Germany with our interactive map

Lisää tähän omat suosikkisi. Tallenna, lajittele, jaa ja tulosta valintasi ja suunnittele koko matkasi Saksaan.

0 suosikkia valittu

What travellers from around the world are saying

Blutenfest des Rotes Moselweinbergpfirsich


We hebben éven moeten oefenen, maar na een tijdje rolde Rote Moselweinbergpfirsich vanzelf uit onze mond. Toch kan je in Cochem ook gewoon Rud Peesche zeggen, het plaatselijke dialect voor deze kleine perzik met haar robijnrode vruchtvlees die overal in de Moezelvallei groeit. Terwijl de wijngaarden er nog kaal bijliggen, zijn de roze bloemen van de Moezel-Wijnbergperzik al een fleurige voorbode van de lente. Goed nieuws voor de plaatselijke wijnboeren dus, maar ook voor al wie dol is op perziken, want dan wordt er in Cochem smakelijk gefeest.

lue lisää »



Voor de ene is het een stukje Frankrijk in Duitsland, voor de andere is het een stukje Duitsland dat ook in Frankrijk niet zou misstaan. Wij houden het bij typisch Duits met een stevige Franse twist: Saarland. De kleinste Duitse deelstaat ging een paar keer over en weer tussen beide landen, was tweemaal op zichzelf en werd in 1957 definitief bij Duitsland ingelijfd. Het resultaat is een grensoverschrijdende kruisbestuiving van savoir-vivre en savoir-faire die zich vooral in de lokale gastronomie laat gelden. Wij trokken in Saarland letterlijk van de ene rijk gedekte tafel naar de andere, gingen er tafeltoeren en lieten ons galant overtuigen van het feit dat je van 'een schone tafel' wél kan eten.

lue lisää »

Crazy SB Waschsalon

Crazy SB Waschsalon

Quando estamos viajando, nada como ter uma lavanderia perto para as horas de aperto. Não tem como não notar essa lavanderia toda "modernosa". Crazy SB Waschsalon chama a atenção por suas centenas de meias penduradas. Uma decoração perfeita para o ambiente. Eu não cheguei a lavar nenhuma roupa na minha estádia em Dresden, mas se ficasse mais uns dias, teria voltado lá de certeza. Fica na Louisenstraße 6, aberto todos os dias das 06h - 23h.

lue lisää »

Travel Bookshop

Travel Bookshop - para os apaixonados por viagem

As coisas mais legais, sem dúvidas eu encontrei em Neustadt. É a região mais alternativa e legal de Dresden. Foi lá que eu vi uma das Lojas de Livros de Viagem mais legais. É aquela loja/livraria/papelaria que você vai querer comprar tudo. Passei uma boa hora lá dentro, folheando (porque ler em alemão, nem em sonho!) todos os guias, livros. Comprei uns postais lindos. Bobeei por não ter comprado uns mapas antigos, eram lindos.

lue lisää »



Para ter uma vista incrível de Dresden, vale muito a pena pegar o monorail em Loschwitz. Além de ver a cidade, você ainda terá uma vista privilegiada da Ponte Azul - Blaueswunder.

lue lisää »


1000 e 1 passagem

Em Neustadt tem a Kunsthofphpassage, que é uma passagem incrível. Ela tem vários prédios "temáticos". O azul por exemplo quando chove, a água nos canos vira música. Fora os prédios, ainda tem várias lojas bacanas e cafés charmosos para você aproveitar. #youngDresden #mustsees #shopping #cafés

lue lisää »

Obras incríveis

Albertinum: um museu de arte moderna de 125 anos, que foi reaberto em 2010, após uma reforma de 51 milhões de euros. A coleção de retratos começa com um dos pintores alemães mais românticos, Caspar David Friedrich, e termina com seu artista vivo mais famoso, Gerhard Richter, sendo que ambos passaram a infância em Dresden. Você vai encontrar desde a Bailarina de Degas, a Monet, Manet, Rodin, Van Gogh. A entrada Vista 10€

lue lisää »

Zwinger Palace

O Chateau de Versailles de Dresden

O Zwinger Palace é um dos melhores exemplos da arquitetura barroca tardia na Alemanha. Construído entre 1710 e 1728 pelo arquiteto Pöppelmann, o Palácio Zwinger foi usado para grandes festas e torneios. Hoje, o complexo barroco de pavilhões, galerias e pátios interiores é a casa de grandes museus e obras. A Madonna Sistina de Rafael você encontrará lá. O acervo de Porcelana tambem é belíssimo. O Arsenal também é muito interessante se você curte trajes e armas. Se você não quiser entrar em nenhum museu, vá pelo menos para andar pelos jardins e admirar o "Kronentor", que é o portão com a coroa.

lue lisää »

Tekstikoon muuttaminen

Kaksi hyödyllistä näppäinyhdistelmää selaimen tekstikoon muuttamiseksi:

Suurenna: +

Pienennä: +

Lisäohjeita saat selaimen valmistajalta napsauttamalla kuvaketta: